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喷雾干燥在药品生产中应用较多,喷雾干燥塔分为离心式、气流式、压力式,传统的喷雾干燥法生产无菌原料药过程中在不溶性微粒、无菌、均一性、有效成分降解等方面存在质量风险,应该针对性地在设备设计、清洁、灭菌、无菌粉冷却、混粉、环境控制等方面对各种风险加以严格控制,才能有效地生产出高品质的无菌原料药。 相似文献
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膨胀干燥过程是合成橡胶后处理工艺的重要组成部分,目前对膨胀干燥过程进行研究的部分理论的计算结果与实际情况存在很大的偏差。文章根据能量守恒的观点,对合成橡胶膨胀干燥过程进行了理论分析,通过热平衡计算量化了影响生产的因素,使之更符合生产实际情况,具有一定的理论指导意义。 相似文献
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根据猕猴桃的褐变机理,选择不同浓度的褐变抑制剂,通过正交试验设计并采用国内先进的低温气流膨化干燥技术,获得猕猴桃片的最佳非硫护色工艺。 相似文献
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Docea A.G. Fianu Richard A. Sallah Augusta Ayertey 《International Journal of Consumer Studies》2005,29(1):34-40
The effect of sunlight and drying methods on the strength of Real Wax printed cotton fabrics produced in Ghana was determined. Warp and weft specimens were washed using the Standard Launder‐Ometer (Gyrowash 315). Each laundered or unlaundered specimen was aired or dried on a flat surface or on clothesline in the sun or shade for 42 h. The breaking strengths of controlled and treated specimens were determined using the tensile testing machine (Hounsfield H5K‐S) and the average percentage loss in strength calculated. The analysis of variance and least significant difference for the separation of means were used to test significant differences between the treatments. Whether dried or aired, sunlight caused more loss in strength than shade. Laundered specimens lost more strength in the sun or shade than those unlaundered. Specimens dried or aired on a flat surface in the sun or shade lost more strength than those on clothesline. There were significant differences (P ≤ 0.05) as a result of the different treatments in the warp direction. For the weft specimens, there was a significant difference between only the aired and washed specimens. Conclusions and future research directions are discussed. 相似文献
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羟基喜树碱壳聚糖纳米冻干粉的制备及表征 总被引:1,自引:0,他引:1
为研究制备载羟基喜树碱的叶酸-壳聚糖纳米冻干粉的制备方法,以羟基喜树碱、叶酸、壳聚糖、三聚磷酸钠为原料,以葡萄糖和甘露醇为保护剂,应用真空冷冻干燥技术,制备了载羟基喜树碱的叶酸-壳聚糖纳米粒冻干粉。以冻干粉外观及在水中再分散性为指标,分别考察了冻干保护剂的种类、体积分数、用量及加入方式对冻干的影响。并利用扫描电镜及透射电镜对冻干粉的微观形态进行观察。结果表明,甘露醇作为冻干保护剂优于葡萄糖。当甘露醇体积分数为8%,与纳米粒水分散体系体积比为1∶1时,所制备的冻干粉呈颜色均一、外表光滑、致密松脆的完整的饼状,且在水中再分散迅速,无任何悬浮物,成均一乳状胶体。在扫描电镜下观察冻干粉呈花瓣形,再分散后于透射电镜下观察,纳米粒子呈规则球形,大小均匀,平均粒径约200 nm左右。该工艺所制备得冻干粉针剂有望成为羟基喜树碱的新剂型。 相似文献
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运用层次分析法对葵花子保质干燥进行评价,并提出全面的定量化和定性化的层次结构评价模式和总体评价方法。首先建立葵花子干燥品质优选的层次分析结构模型及判断矩阵,然后进行层次排序,并对判断矩阵进行一致性检验,在定性、定量指标转换的基础上形成评价方法。生产试验表明该方法简易可行,结论符合实际。 相似文献